Ask your vet about the benefits of including ProHeart 12 in your dog's annual wellness visit—it's an easy way to keep them protected, and can be administered during your vet visit.
*Caused by Dirofilaria immitis.
With ProHeart 12, heartworm disease protection doesn't have to be a hassle.
The short answer: mosquitoes. A single bite from an infected mosquito can put your dog at risk for developing heartworm disease.
In three well-controlled studies, ProHeart 12:2
Was 100% effective against heartworm disease* in dogs
Was demonstrated to be safe for most types of dogs over 12 months, including:
Dogs pregnant or nursing
Collies sensitive to ivermectin—a common ingredient in monthly heartworm products
Had a similar adverse event profile to Heartgard® Plus
Please see full Prescribing Information for ProHeart 12.
*Caused by Dirofilaria immitis.
Heartgard is a registered trademark of Boehringer Ingelheim.
ProHeart 6 is a twice-yearly dose to prevent heartworm disease in dogs
20 million doses sold over a 10‑year period3
Demonstrated safe in special populations like:4
Dogs pregnant or nursing
Dogs sensitive to ivermectin—a common ingredient in monthly products for heartworm disease
Many common medicines were given at the same time in clinical trials
Please see full Prescribing Information for ProHeart 6.
IMPORTANT SAFETY INFORMATION: See Prescribing Information for ProHeart 6 and ProHeart 12. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products.
* Caused by Dirofilaria immitis.
† ProHeart 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.
‡ From an infected mosquito
References:
AHS Canine Guidelines 2024. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Canine_Guidelines.pdf?1580934824. Accessed January 21, 2025.
McTier, T.L., Kryda, K., Wachowski, M. et al. ProHeart® 12, a moxidectin extended-release injectable formulation for prevention of heartworm (Dirofilaria immitis) disease in dogs in the USA for 12 months. Parasites Vectors 12, 369 (2019).
ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis. Inc.
ProHeart 6 Freedom of Information Summary: 2001/06/06 Original NADA 141-189.