ProHeart 12 provides one full year of heartworm disease* protection with only one dose.

Ask your vet about the benefits of including ProHeart 12 in your dog's annual wellness visit—it's an easy way to keep them protected, and can be administered during your vet visit.

*Caused by Dirofilaria immitis.

With ProHeart 12, heartworm disease protection doesn't have to be a hassle.

What Pet Parents & Vets are Saying

How Do Dogs Get Infected With Heartworms?

The short answer: mosquitoes. A single bite from an infected mosquito can put your dog at risk for developing heartworm disease.

  1. An infected mosquito bites your dog, infecting it with heartworm larvae.
  2. The heartworms then mature inside your dog, living in major vessels around the heart and even sometimes inside the heart itself.
  3. It could take longer than 7 months for the heartworms to be detectable with routine testing. An adult heartworm can grow up to a foot in length, living inside your dog’s heart and lungs.1

ProHeart 12 Is Effective & Safe

In three well-controlled studies, ProHeart 12:2

  • Was 100% effective against heartworm disease* in dogs

  • Was demonstrated to be safe for most types of dogs over 12 months, including:

    • Dogs pregnant or nursing

    • Collies sensitive to ivermectin—a common ingredient in monthly heartworm products

  • Had a similar adverse event profile to Heartgard® Plus

Please see full Prescribing Information for ProHeart 12.

*Caused by Dirofilaria immitis.
Heartgard is a registered trademark of Boehringer Ingelheim.

ProHeart 6® (moxidectin): Another Reliable Option

ProHeart 6 is a twice-yearly dose to prevent heartworm disease in dogs

  • 20 million doses sold over a 10‑year period3

  • Demonstrated safe in special populations like:4

    • Dogs pregnant or nursing

    • Dogs sensitive to ivermectin—a common ingredient in monthly products for heartworm disease

  • Many common medicines were given at the same time in clinical trials

Please see full Prescribing Information for ProHeart 6.

2 x per year

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Frequently Asked Questions

IMPORTANT SAFETY INFORMATION: See Prescribing Information for ProHeart 6 and ProHeart 12. Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products.

* Caused by Dirofilaria immitis.

† ProHeart 12 is indicated for the treatment of existing larval and adult hookworm (Ancylostoma caninum and Uncinaria stenocephala) infections.

‡ From an infected mosquito

References:

  1. AHS Canine Guidelines 2024. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2020_AHS_Canine_Guidelines.pdf?1580934824. Accessed January 21, 2025.

  2. McTier, T.L., Kryda, K., Wachowski, M. et al. ProHeart® 12, a moxidectin extended-release injectable formulation for prevention of heartworm (Dirofilaria immitis) disease in dogs in the USA for 12 months. Parasites Vectors 12, 369 (2019).

  3. ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis. Inc.

  4. ProHeart 6 Freedom of Information Summary: 2001/06/06 Original NADA 141-189.

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