How is Simparica Trio different from other preventatives?

Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, five types of ticks, fleas, roundworms and hookworms, all in one monthly chewable.

Is Simparica Trio safe?

Simparica Trio has been demonstrated safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs.

How often do you give Simparica Trio?

Give a Simparica Trio chewable to your dog once a month.

How do I switch from another heartworm medication or tick and flea medication?

Talk to your veterinarian about switching to Simparica Trio from another preventive medication to ensure your dog is kept protected through the process.

Do I need a prescription for Simparica Trio?

Yes. Your veterinarian can prescribe the correct dose for your dog. Talk to your vet today about Simparica Trio.

What if I’m late giving a Simparica Trio dose?

If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

How fast does Simparica Trio work to kill ticks and fleas?

Simparica Trio works to get rid of ticks and fleas on dogs fast. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

When can I start Simparica Trio for a puppy?

You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs.

Can Simparica Trio help prevent Lyme infections?

Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing deer ticks.

Simparica Trio for Pet Owners

The First FDA-Approved Product of Its Kind

Simparica Trio is a once-a-month chewable that protects your dog with three proven ingredients designed for defense. It's available from your vet with a prescription and comes with a 100% satisfaction guarantee.

Protects dogs against heartworm disease, ticks & fleas, roundworms & hookworms.
The only FDA-approved product to kill 6 types of ticks, including the deer tick that may carry Lyme disease.
Demonstrated safe for puppies as young as 8 weeks old, weighing at least 2.8 lbs.

Earn Rewards with eligible purchases to help pay for future vet care.

Get Rewards

It’s Time to Enhance Your Dog’s Protection

Studies to support FDA approval showed that 1 dose of Simparica Trio provided 100% protection against heartworm disease.
Proven to kill 6 types of ticks.
Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours, and achieved 100% effectiveness in 8 hours in a study.
Treats and controls roundworms and hookworms to protect your dog from intestinal parasites.

Why Your Dog Needs Protection

See why it’s so important to protect your best friend.

Heartworm disease can be fatal, and it only takes one bite from an infected mosquito.

Heartworm disease is a year-round threat
Heartworm disease has been diagnosed in all 50 states
Even with routine testing, heartworm disease can take up to 9 months to detect.¹
Heartworm disease can be deadly

Deer ticks can infect your dog with Lyme disease, which can cause recurring health problems like arthritis or kidney failure.⁶

Lyme disease can be hard to diagnose.
It just takes 1 infected tick to spread disease that can be harmful, even deadly, to dogs.^7,8
Some ticks can survive freezing temperatures and become active when the temperature rises to 40°F.^9,10
Simparica Trio starts working fast, and is FDA-approved to block infections that may cause Lyme disease by killing deer ticks.

Ticks are found year-round, in every part of the U.S.²

Ticks are responsible for transmitting at least 15 different serious diseases to dogs, including Lyme disease.³
Simparica Trio is the only FDA-approved parasiticide proven to kill and block infections from 6 kinds of ticks, including the deer tick that may cause Lyme disease.

Fleas can quickly infest your home.

Fleas start to bite within 5 minutes.⁴ Those bites can also lead to infectious diseases.⁵
A dog’s reaction to flea bites may vary from sores and inflammation to hair loss.
Fleas can lay up to 1300 eggs within 50 days,⁴ but Simparica Trio kills them before they can even lay eggs. In studies it started killing within 4 hours, and achieved 100% effectiveness in 8 hours.

Roundworms and hookworms can hurt your dog.

Intestinal parasites can grow throughout the intestines.
Symptoms include stomach swelling, vomiting, diarrhea and dehydration.
Infected dogs can contaminate the home, putting other pets and people at risk.
Puppies are more commonly infected through breast milk and exposure before birth.

Resources For You

Frequently Asked Questions

: Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, 6 types of ticks, fleas, roundworms and hookworms, all in only one monthly chewable.
: Simparica Trio has been demonstrated safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs.
: Give a Simparica Trio chewable to your dog once a month.
: Talk to your veterinarian about switching to Simparica Trio from another preventive medication to ensure your dog is kept protected through the process.
: Yes. Your veterinarian can prescribe the correct dose for your dog. Talk to your vet today about Simparica Trio.
: If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.
: Simparica Trio works to get rid of ticks and fleas on dogs fast. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.
: You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs.
: Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing deer ticks.

Important Safety Information: See Prescribing Information. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis (black-legged tick), Rhipicephalus sanguineus (brown dog tick), and Haemaphysalis longicornis (Asian longhorned tick) for one month in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater. SIMPARICA TRIO is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks.

References:

AHS Canine Guidelines 2018. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2018-AHS-Canine-Guidelines-181114.pdf?1542248135.
Centers for Disease Control and Prevention. Geographic distribution of ticks that bite humans. http://www.cdc.gov/ticks/geographic_distribution.html. Updated June 1, 2015. Accessed March 19, 2019.
Companion Animal Parasite Council. Ticks. April 12, 2017. https://capcvet.org/guidelines/ticks. Accessed September 10, 2019.
Byron L. Blagburn, BS, MS, PhD.*, Michael W. Dryden, DVM, PhD. Biology, Treatment, and Control of Flea and Tick Infestations. 2009; 4.
Flea Allergy Dermatitis in Cats and Dogs. VetStreet website. http://www.vetstreet.com/care/flea-allergy-dermatitis-in-cats-and-dogs. Updated Apr 22, 2014. Accessed Mar 21, 2019.
Lyme Disease. CDC. https://www.cdc.gov/ticks/tickbornediseases/lyme.html. Accessed March 14, 2019.
How ticks spread disease. Centers for Disease Control and Prevention website. https://www.cdc.gov/ticks/life_cycle_and_hosts.html. Updated January 10, 2019. Accessed March 19, 2019.
Little SE. Changing paradigms in understanding transmission of canine tick-borne diseases: the role of interrupted feeding and intrastadial transmission. In: Proceedings of the 2nd Canine Vector-Borne Disease (CVBD) Symposium; April 25-28, 2007; Sicily, Italy.
Fleas, ticks & your pet. Companion Animal Parasite Council (CAPC) website. http://www.petsandparasites.org/images/uploads/documents/BC-3844_CAPC_FleaTick_one-color_04.pdf. Updated March 2011. Accessed March 25, 2019.
Eisen RJ, Eisen L, Ogden NH, Beard CB. Linkages of Weather and Climate With Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae), Enzootic Transmission of Borrelia burgdorferi, and Lyme Disease in North America. J Med Entomol. 2016 Mar;53(2):250-61. doi: 10.1093/jme/tjv199. PMID: 26681789; PMCID: PMC4844560.

ZPC-01080R7

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

#react-view{ margin-top: 2rem; } .nojs-message{ position: absolute; z-index: 10; top: 0; width: 100%; text-align: center; padding: 1rem; background: #d60000; color: white; font-weight: 700; font-size: 18px; } This site requires JavaScript. Your browser has JavaScript disabled, please turn it on in your browser settings.

One Chew, Triple Protection